Spectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma
Multiple BRAF inhibitor resistance mechanisms have been described, however their relative frequency, clinical correlates, and effect on subsequent therapy have not been assessed in patients with metastatic melanoma. Excised progressing BRAFV600 mutant melanoma metastases (Prog) from patients treated with dabrafenib (n=22) or vemurafenib (n=8) were analyzed for known resistance mechanisms. Oncogenic signaling in Prog and matched pre-treatment tumors was examined using gene expression analysis. R...
Provenance — who produced it, who reused it
Linked to 25 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Targeting mitochondrial biogenesis to overcome drug resistance t... 2016 · 299 cites
- Molecular stratification of metastatic melanoma using gene expre... 2015 · 192 cites
- Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark... 2020 · 154 cites
- Tumor-associated B-cells induce tumor heterogeneity and therapy... 2017 · 141 cites
- miR-579-3p controls melanoma progression and resistance to targe... 2016 · 115 cites
- Oncogenic PI3K/AKT promotes the step-wise evolution of combinati... 2018 · 106 cites
- TRIM15 and CYLD regulate ERK activation via lysine-63-linked pol... 2021 · 86 cites
- MITF Modulates Therapeutic Resistance through EGFR Signaling 2015 · 84 cites
- Genomic hallmarks and therapeutic implications of G0 cell cycle... 2023 · 74 cites
15 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently