Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and acts as a general amplifier of transcription. However, the available data did not readily discriminate between direct and indirect effects of Myc on RNA biogenesis. We addressed this issue with genome-wide chro...
Provenance — who produced it, who reused it
Linked to 9 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Selective transcriptional regulation by Myc in cellular growth c... 2014 · 526 cites
- Degradation dynamics of microRNAs revealed by a novel pulse-chas... 2016 · 191 cites
- Plasma cell differentiation is coupled to division-dependent DNA... 2016 · 143 cites
- MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by... 2017 · 114 cites
- B cell activation and plasma cell differentiation are inhibited... 2018 · 114 cites
4 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently