Pseudo-temporal ordering of individual cells reveals regulators of differentiation
Single-cell expression profiling by RNA-Seq promises to exploit cell-to-cell variation in gene expression to reveal regulatory circuitry governing cell differentiation and other biological processes. Here, we describe Monocle, a novel unsupervised algorithm for ordering cells by progress through differentiation that dramatically increases temporal resolution of expression measurements. This reordering unmasks switch-like changes in expression of key regulatory factors, reveals sequentially orga...
Provenance — who produced it, who reused it
Linked to 23 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Slingshot: cell lineage and pseudotime inference for single-cell... 2018 · 3,351 cites
- Single-cell entropy for accurate estimation of differentiation p... 2017 · 377 cites
- A statistical approach for identifying differential distribution... 2016 · 329 cites
- AutoImpute: Autoencoder based imputation of single-cell RNA-seq... 2018 · 187 cites
- scEpath: energy landscape-based inference of transition probabil... 2018 · 143 cites
- Fast and accurate single-cell RNA-seq analysis by clustering of... 2016 · 129 cites
- Tempora: Cell trajectory inference using time-series single-cell... 2020 · 92 cites
- McImpute: Matrix Completion Based Imputation for Single Cell RNA... 2019 · 82 cites
- Mpath maps multi-branching single-cell trajectories revealing pr... 2016 · 78 cites
13 further papers cite this accession but reuse could not be confirmed.
Deep data QC
99/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0