Alzheimer's disease and the normal aged brain (steph-affy-human-433773)
Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnosis, early detection, and tracking of this disorder, and provide novel targets for the discovery of interventions to treat and prevent this disorder. Information about the genes that are preferentially...
Provenance — who produced it, who reused it
Linked to 178 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Rare coding variants in the phospholipase D3 gene confer risk fo... 2013 · 476 cites
- Epigenome-wide study uncovers large-scale changes in histone ace... 2018 · 269 cites
- Sphingolipid Metabolic Pathway: An Overview of Major Roles Playe... 2013 · 193 cites
- Selective Neuronal Vulnerability in Alzheimer’s Disease: A Netwo... 2020 · 191 cites
- Warburg-like metabolic transformation underlies neuronal degener... 2022 · 178 cites
- Dysregulation of multiple metabolic networks related to brain tr... 2020 · 163 cites
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a... 2021 · 152 cites
- Concerted Perturbation Observed in a Hub Network in Alzheimer’s... 2012 · 113 cites
- Assembly and Interrogation of Alzheimer’s Disease Genetic Networ... 2015 · 107 cites
- Identification of Differentially Expressed Genes through Integra... 2016 · 102 cites
- Alzheimer’s disease master regulators analysis: search for poten... 2018 · 95 cites
- Identification and immunological characterization of cuproptosis... 2022 · 93 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- Genomic convergence and network analysis approach to identify ca... 2014 · 90 cites
- AlzGPS: a genome-wide positioning systems platform to catalyze m... 2021 · 88 cites
- Bioinformatics and Network Pharmacology Identify the Therapeutic... 2021 · 87 cites
- Exploring the Transcriptome of Ciliated Cells Using In Silico Di... 2012 · 87 cites
- Ranking metrics in gene set enrichment analysis: do they matter? 2017 · 80 cites
- PathNet: a tool for pathway analysis using topological informati... 2012 · 79 cites
- Identification of age- and gender-associated long noncoding RNAs... 2019 · 79 cites
- Integrated multi-omics analysis of Alzheimer’s disease shows mol... 2023 · 77 cites
57 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.