RNAseq Analysis of Formalin-Fixed Paraffin-Embedded Prostate Cancer Tissues
In an effort to identify biomarkers of recurrence, we have performed global RNA-sequencing on 106 formalin-fixed, paraffin-embedded (FFPE) prostatectomy samples from 100 patients at three independent sites, and identified a new set of biomarkers of biochemical recurrence composed of a 24-gene panel. We validated this 24-gene panel on an independent publicly available dataset of 140 patients and this new panel outperformed previously published markers based on cell proliferation gene sets in term...
Provenance — who produced it, who reused it
Linked to 30 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Development and Validation of a 28-gene Hypoxia-related Prognost... 2018 · 158 cites
- Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer... 2014 · 153 cites
- New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and... 2020 · 78 cites
27 further papers cite this accession but reuse could not be confirmed.
Deep data QC
83/100 · BStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The B grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0