SCML2 Establishes the Male Germline Epigenome
Gametogenesis is dependent on the expression of germline-specific genes. However, it remains unknown how the germline epigenome is distinctly established from that of somatic lineages. Here we show that genes commonly expressed in somatic lineages and spermatogenesis-progenitor cells undergo repression in a genome-wide manner in late stages of the male germline and identify underlying mechanisms. SCML2, a germline-specific subunit of a Polycomb repressive complex 1 (PRC1), establishes the unique...
Provenance — who produced it, who reused it
Linked to 9 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- SCML2 Establishes the Male Germline Epigenome through Regulation... 2015 · 155 cites
- Dynamic reorganization of open chromatin underlies diverse trans... 2017 · 141 cites
- Attenuated chromatin compartmentalization in meiosis and its mat... 2019 · 141 cites
- Super-enhancer switching drives a burst in gene expression at th... 2020 · 77 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
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measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently