Programming and inheritance of parental DNA methylomes in mammals
The reprogramming of parental methylomes is essential for embryonic development. In mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted to oxidized bases. These paternal oxidized bases and maternal 5mCs are believed to be passively diluted by cell divisions. By generating single-base resolution, allele-specific DNA methylomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well as single-base-resolution maps of oxidized cytosine bases for...
Provenance — who produced it, who reused it
Linked to 15 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Broad histone H3K4me3 domains in mouse oocytes modulate maternal... 2016 · 662 cites
- Genome-wide analysis in the mouse embryo reveals the importance... 2020 · 163 cites
- Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Emb... 2018 · 138 cites
- Early Developmental and Evolutionary Origins of Gene Body DNA Me... 2015 · 122 cites
- Epigenetic clocks reveal a rejuvenation event during embryogenes... 2021 · 121 cites
- Evolutionary transition between invertebrates and vertebrates vi... 2019 · 78 cites
8 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently