MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts to treat normal pressure hydrocephalus. We then used RNA-Seq to compare expression patterns between geographically distinct regions of gliomas and computational deconvolution to estimate cell type-s...
Provenance — who produced it, who reused it
Linked to 10 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- DNA-methylation-mediated activating of lncRNA SNHG12 promotes te... 2020 · 346 cites
- Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Dif... 2016 · 270 cites
- The mitotic kinesin KIF11 is a driver of invasion, proliferation... 2015 · 177 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
99/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0