Cross-tissue methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer’s disease neuropathology
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is characterized by progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of methylomic variation in AD using samples from three independent human post-mortem brain cohorts. We identified a differentially methylated region in the ankyrin 1 (ANK1) gene that was associated with neuropathology in the entorhinal cortex, a primary site of AD manifestation. This region was confirmed as being substant...
Provenance — who produced it, who reused it
Linked to 20 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- An epigenetic clock analysis of race/ethnicity, sex, and coronar... 2016 · 788 cites
- BECon: a tool for interpreting DNA methylation findings from blo... 2017 · 263 cites
- DNA methylation analysis on purified neurons and glia dissects a... 2018 · 256 cites
- Recalibrating the epigenetic clock: implications for assessing b... 2020 · 204 cites
- The cerebellum ages slowly according to the epigenetic clock 2015 · 198 cites
- Systematic underestimation of the epigenetic clock and age accel... 2019 · 148 cites
- Genetic architecture of epigenetic and neuronal ageing rates in... 2017 · 134 cites
- DNA methylation of TOMM40-APOE-APOC2 in Alzheimer’s disease 2018 · 98 cites
- Brain DNA Methylation Patterns in CLDN5 Associated With Cognitiv... 2021 · 72 cites
10 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently