Global loss of DNA methylation uncovers intronic enhancers in genes
We used HCT116 colorectal cancer cells with and without mutations in DNA methyltransferases (resulting in a 95% reduction in global DNA methylation levels) to study the relationship between DNA methylation, histone modifications, and gene expression. (The double knockout cell line is called DKO1)
Provenance — who produced it, who reused it
Linked to 7 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Global loss of DNA methylation uncovers intronic enhancers in ge... 2014 · 171 cites
- The role of DNA methylation in directing the functional organiza... 2015 · 126 cites
- Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining... 2020 · 95 cites
- Links between DNA methylation and nucleosome occupancy in the hu... 2017 · 84 cites
3 further papers cite this accession but reuse could not be confirmed.
Deep data QC
100/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0