Rapid neurogenesis through transcriptional activation in human stem cell (RNA-Seq)
Advances in cellular reprogramming and stem cell differentiation now enable ex vivo studies of human neuronal differentiation. However, it remains challenging to elucidate the underlying regulatory programs because differentiation protocols are laborious and often result in low neuron yields. Here, we overexpressed two murine Neurogenin transcription factors in human induced pluripotent stem cells, and obtained neurons with bipolar morphology in four days at greater than 90% purity. The high pur...
Provenance — who produced it, who reused it
Linked to 5 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- SUPPA2: fast, accurate, and uncertainty-aware differential splic... 2018 · 730 cites
- Primate-restricted KRAB zinc finger proteins and target retrotra... 2020 · 95 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
58/100 · FStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The F grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0