Epigenetic signatures of alcohol abuse and hepatitis infection during hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. Altered DNA methylation landscapes are ubiquitous features of cancer. Interpretation of epigenetic aberrations in HCC is confounded by effects of multiple etiologic drivers and underlying cirrhosis in most cases. We globally profiled the DNA methylome of 34 normal livers and 122 primary liver disease tissues arising in the setting of chronic hepatitis B (HBV) or C (HCV) viral infection, alcoholism (EtOH),...
Provenance — who produced it, who reused it
Linked to 12 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Reference-free deconvolution of DNA methylation data and mediati... 2016 · 265 cites
- Age-related DNA methylation changes are tissue-specific with ELO... 2018 · 227 cites
- Cell-composition effects in the analysis of DNA methylation arra... 2015 · 134 cites
- Genome-wide discovery and validation of diagnostic DNA methylati... 2019 · 115 cites
- DNA Hypomethylation and Histone Variant macroH2A1 Synergisticall... 2016 · 104 cites
- DNA methylation age is accelerated in alcohol dependence 2018 · 103 cites
- Deconvolution of cellular subsets in human tissue based on targe... 2020 · 84 cites
- Methylomic profiling and replication implicates deregulation of... 2017 · 84 cites
3 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently