Transcription factor binding dynamics during human ES cell differentiation
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome wide binding data for 38 transcription factors with extensive epigenome and transcriptional data across the differentiation of human embryonic stem cells to the three germ layers. We describe core regulatory dynamics and show the lineage specific behavior of selected factors. In addition to th...
Provenance — who produced it, who reused it
Linked to 17 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Dynamics of genome reorganization during human cardiogenesis rev... 2019 · 175 cites
- Esophageal Organoids from Human Pluripotent Stem Cells Delineate... 2018 · 162 cites
- Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Int... 2019 · 110 cites
- GATA6 defines endoderm fate by controlling chromatin accessibili... 2021 · 76 cites
- Sequential enhancer state remodelling defines human germline com... 2022 · 72 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
10 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently