Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study [gastric tumors]
Gastric cancer, a leading cause of cancer related deaths, is a heterogeneous disease, with little consensus on molecular subclasses and their clinical relevance. We describe four molecular subtypes linked with distinct patterns of molecular alterations, disease progression and prognosis viz. a) Microsatellite Instable: hypermutated intestinal subtype tumors occurring in antrum, best overall prognosis, lower frequency of recurrence (22%), with liver metastasis in 23% of recurred cases b) Mesenchy...
Provenance — who produced it, who reused it
Linked to 213 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- m6A regulator-mediated methylation modification patterns and tum... 2020 · 1,052 cites
- Single-cell dissection of intratumoral heterogeneity and lineage... 2021 · 273 cites
- NSUN2 modified by SUMO-2/3 promotes gastric cancer progression a... 2021 · 238 cites
- CD36 mediates palmitate acid-induced metastasis of gastric cance... 2019 · 222 cites
- A long non-coding RNA signature to improve prognosis prediction... 2016 · 216 cites
- IGF2BP3 functions as a potential oncogene and is a crucial targe... 2017 · 147 cites
- Stromal-Immune Score-Based Gene Signature: A Prognosis Stratific... 2019 · 145 cites
- LncRNA MAGI2-AS3 Is Regulated by BRD4 and Promotes Gastric Cance... 2019 · 142 cites
- TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer pr... 2020 · 141 cites
- HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferat... 2019 · 124 cites
- PreMSIm: An R package for predicting microsatellite instability... 2020 · 114 cites
- Lysyl oxidase promotes liver metastasis of gastric cancer via fa... 2019 · 114 cites
- Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer... 2021 · 113 cites
- Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mit... 2021 · 113 cites
- <i>Helicobacter pylori</i> ‐induced miR‐135b‐5p promotes cisplat... 2018 · 109 cites
- m6A modification-mediated BATF2 acts as a tumor suppressor in ga... 2020 · 107 cites
- Estrogen-related receptor gamma functions as a tumor suppressor... 2018 · 106 cites
- Development and Validation of a Prognostic Nomogram for Gastric... 2020 · 101 cites
- TEAD1/4 exerts oncogenic role and is negatively regulated by miR... 2017 · 93 cites
- PODXL, negatively regulated by KLF4, promotes the EMT and metast... 2018 · 90 cites
- A three‐lncRNA expression signature associated with the prognosi... 2017 · 83 cites
- N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses... 2020 · 81 cites
- Integrated analysis reveals potential long non-coding RNA biomar... 2019 · 80 cites
- Histone methyltransferase SETD1A interacts with HIF1α to enhance... 2020 · 76 cites
- The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA... 2021 · 76 cites
- <i>H. pylori</i>‐induced NF‐κB‐PIEZO1‐YAP1‐CTGF axis drives gast... 2023 · 73 cites
- IRF6 Is Directly Regulated by ZEB1 and ELF3, and Predicts a Favo... 2019 · 72 cites
- LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance... 2019 · 72 cites
52 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.