Genome-wide modelling of transcription kinetics reveals patterns of RNA processing delays
We descrive a joint model of transcriptional activation and mRNA accumulation, using estrogen receptor ERα activation in MCF-7 breast cancer cell line, which can be used for inference of transcription rate, RNA processing delay and degradation rate given data from high-throughput sequencing time course experiments.
Provenance — who produced it, who reused it
Linked to 12 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Co-transcriptional R-loops are the main cause of estrogen-induce... 2016 · 314 cites
- Genome-wide modeling of transcription kinetics reveals patterns... 2015 · 106 cites
- Temporal dynamic reorganization of 3D chromatin architecture in... 2019 · 84 cites
9 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently