Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
We developed an affinity purification approach to isolate tagged nuclei in mice (similar to INTACT; [Deal R.B. and Henikoff S. A simple method for gene expression and chromatin profiling of individual cell types within a tissue. Dev. Cell 18,1030-1040. (2010)]) and used it to characterize genome-wide patterns of transcription, DNA methylation, and chromatin accessibility in 3 major neuron classes of the neocortex (excitatory pyramidal neurons, parvalbumin (PV)-positive GABAergic interneurons, an...
Provenance — who produced it, who reused it
Linked to 14 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq... 2019 · 535 cites
- Viral manipulation of functionally distinct interneurons in mice... 2020 · 262 cites
- Enhancer viruses for combinatorial cell-subclass-specific labeli... 2021 · 207 cites
- Layer-specific chromatin accessibility landscapes reveal regulat... 2017 · 91 cites
- HOME: a histogram based machine learning approach for effective... 2019 · 72 cites
8 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently