N6-methyladenosine Modulates Messenger RNA Translation Efficiency
N6-methyladenosine (m6A) is the most abundant internal messenger (mRNA) modification in mammalian mRNA. This modification is reversible and non-stoichiometric, which potentially adds an additional layer of variety and dynamic control of mRNA metabolism. The m6A-modified mRNA can be selectively recognized by the YTH family “reader” proteins. The preferential binding of m6A-containing mRNA by YTHDF2 is known to reduce the stability of the target transcripts; however, the exact effects of m6A on tr...
Provenance — who produced it, who reused it
Linked to 11 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- A Unified Model for the Function of YTHDF Proteins in Regulating... 2020 · 855 cites
- Dynamic methylome of internal mRNA N7-methylguanosine and its re... 2019 · 317 cites
- METTL3 promotes tumour development by decreasing APC expression... 2021 · 193 cites
- RETRACTED: YTHDF1 Facilitates the Progression of Hepatocellular... 2020 · 85 cites
- riboCIRC: a comprehensive database of translatable circRNAs 2021 · 82 cites
- YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A... 2021 · 75 cites
- CircRHBDD1 augments metabolic rewiring and restricts immunothera... 2022 · 74 cites
- Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with... 2022 · 71 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently