High-throughput sequencing of DNA G-quadruplex structures in the human genome
Nucleic acid secondary structures play a critical role in the regulation of biological processes. Genome-wide detection of DNA and RNA secondary structures is essential to identify pathways that are regulated by nucleic acid folding. There are no methods to interrogate DNA secondary structure formation on a genome-wide scale. We present G4-Seq, a method that applies the concept of polymerase interference at G-quadruplex (G4) DNA secondary structures to a human genome scale by massively parallel...
Provenance — who produced it, who reused it
Linked to 18 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- CX-5461 is a DNA G-quadruplex stabilizer with selective lethalit... 2017 · 587 cites
- G-quadruplexes are transcription factor binding hubs in human ch... 2021 · 270 cites
- Machine learning model for sequence-driven DNA G-quadruplex form... 2017 · 171 cites
- Alternative splicing modulation by G-quadruplexes 2022 · 135 cites
- Integrative characterization of G-Quadruplexes in the three-dime... 2019 · 129 cites
13 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently