Definition of clinically distinct molecular subtypes in estrogen receptor positive breast carcinomas using genomic grade
Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)-positive subtypes has been inconsistent. Refinement of their molecular definition is therefore needed. Materials and methods: We have previously reported a...
Provenance — who produced it, who reused it
Linked to 170 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- Aerobic glycolysis tunes YAP/TAZ transcriptional activity 2015 · 420 cites
- ZMYND11 links histone H3.3K36me3 to transcription elongation and... 2014 · 355 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- Wnt signaling in triple negative breast cancer is associated wit... 2013 · 251 cites
- LINC02273 drives breast cancer metastasis by epigenetically incr... 2019 · 222 cites
- NRF2 activation promotes the recurrence of dormant tumour cells... 2020 · 215 cites
- Opposing Functions of BRD4 Isoforms in Breast Cancer 2020 · 207 cites
- Taxonomy of breast cancer based on normal cell phenotype predict... 2014 · 198 cites
- The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recu... 2015 · 188 cites
- Demonstrating the feasibility of large-scale development of stan... 2013 · 187 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Changes of N6-methyladenosine modulators promote breast cancer p... 2019 · 168 cites
- Claudin-Low Breast Cancer; Clinical & Pathological Character... 2017 · 162 cites
- Identification of Prognosis-Relevant Subgroups in Patients with... 2013 · 161 cites
- Downregulation of long noncoding RNA MALAT1 induces epithelial-t... 2015 · 151 cites
- EMT is associated with an epigenetic signature of ECM remodeling... 2019 · 148 cites
- BreastMark: An Integrated Approach to Mining Publicly Available... 2013 · 143 cites
- Concordance among gene expression-based predictors for ER-positi... 2012 · 141 cites
- HMGA1 promotes metastatic processes in basal-like breast cancer... 2013 · 134 cites
- DEAD-box helicase DP103 defines metastatic potential of human br... 2014 · 131 cites
- A Targeted RNAi Screen of the Breast Cancer Genome Identifies <i... 2013 · 130 cites
- Anticipatory estrogen activation of the unfolded protein respons... 2014 · 121 cites
- Hypoxia-inducible factor 1 mediates TAZ expression and nuclear l... 2014 · 116 cites
- FAM83D promotes cell proliferation and motility by downregulatin... 2013 · 108 cites
- High-throughput RNAi screening for novel modulators of vimentin... 2012 · 107 cites
- Phosphorylated and sumoylation-deficient progesterone receptors... 2012 · 96 cites
- The gene expression landscape of breast cancer is shaped by tumo... 2012 · 94 cites
- Mitohormesis Primes Tumor Invasion and Metastasis 2019 · 94 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- CDK‐mediated activation of the SCFFBXO28 ubiquitin ligase promot... 2013 · 91 cites
- IMP3 promotes stem-like properties in triple-negative breast can... 2015 · 86 cites
- OTUD7B stabilizes estrogen receptor α and promotes breast cancer... 2021 · 84 cites
- A genomic analysis of mouse models of breast cancer reveals mole... 2014 · 83 cites
- Reprogramming of Amino Acid Transporters to Support Aspartate an... 2019 · 83 cites
- A mechanistic model captures the emergence and implications of n... 2021 · 79 cites
- Therapeutically targeting tumor microenvironment–mediated drug r... 2018 · 76 cites
- Patient-derived xenografts of triple-negative breast cancer repr... 2014 · 74 cites
- Cyclin D1 induction of Dicer governs microRNA processing and exp... 2013 · 74 cites
- SPHK1 regulates proliferation and survival responses in triple-n... 2014 · 73 cites
40 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently