The landscape of accessible chromatin in mammalian pre-implantation embryos
In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation development. However, the global chromatin landscape and its dynamics in this period remain unexplored. Here we report a genome-wide map of accessible chromatin in mouse preimplantation embryos using an improved assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) approach with CRISPR/Cas9-assisted mitochondrial D...
Provenance — who produced it, who reused it
Linked to 12 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Heterochromatin establishment during early mammalian development... 2020 · 147 cites
- DeepHiC: A generative adversarial network for enhancing Hi-C dat... 2020 · 104 cites
- New insights on human essential genes based on integrated analys... 2019 · 100 cites
- Comparative transcriptomics reveals circadian and pluripotency n... 2022 · 86 cites
- Retinoic acid signaling is critical during the totipotency windo... 2021 · 79 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently