Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accurately reflect the pathological progression of disease at each stage were identified and potential molecular markers for early diagnosis uncovered. Pathway analysis revealed dysregulation of the Notch...
Provenance — who produced it, who reused it
Linked to 107 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A... 2020 · 305 cites
- Exosome-mediated secretion of LOXL4 promotes hepatocellular carc... 2019 · 258 cites
- Long noncoding RNA LINC00662 promotes M2 macrophage polarization... 2019 · 233 cites
- Identifying critical transitions and their leading biomolecular... 2012 · 219 cites
- Sphingolipid Metabolic Pathway: An Overview of Major Roles Playe... 2013 · 193 cites
- Identification of Key Pathways and Genes in the Dynamic Progress... 2018 · 186 cites
- ZIC2-dependent OCT4 activation drives self-renewal of human live... 2015 · 173 cites
- Histone methyltransferase SETDB1 regulates liver cancer cell gro... 2015 · 169 cites
- Identification of the Consistently Altered Metabolic Targets in... 2017 · 156 cites
- A hypoxia-related signature for clinically predicting diagnosis,... 2020 · 144 cites
- A human multi-lineage hepatic organoid model for liver fibrosis 2021 · 138 cites
- <scp>FAM</scp>83 family oncogenes are broadly involved in human... 2017 · 128 cites
- RBM15 promotes hepatocellular carcinoma progression by regulatin... 2021 · 111 cites
- Crosstalk between 5-methylcytosine and N6-methyladenosine machin... 2023 · 107 cites
- Lentiviral vector–based insertional mutagenesis identifies genes... 2013 · 101 cites
- Glutaminase 2 is a novel negative regulator of small GTPase Rac1... 2016 · 101 cites
- Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carc... 2012 · 99 cites
- E2f8 mediates tumor suppression in postnatal liver development 2016 · 98 cites
- Early Diagnosis of Hepatocellular Carcinoma Using Machine Learni... 2020 · 97 cites
- βII‐Spectrin (SPTBN1) suppresses progression of hepatocellular c... 2014 · 95 cites
- Elevated TRIP13 drives the AKT/mTOR pathway to induce the progre... 2019 · 91 cites
- Removing batch effects for prediction problems with frozen surro... 2014 · 88 cites
- A distinct p53 target gene set predicts for response to the sele... 2015 · 87 cites
- KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proli... 2014 · 87 cites
- DNA topoisomerase 1 and 2A function as oncogenes in liver cancer... 2018 · 83 cites
- Xmrk, Kras and Myc Transgenic Zebrafish Liver Cancer Models Shar... 2014 · 74 cites
54 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently