Acute myeloid leukemia samples of samples =< 60yrs on HG-U133 plus 2
The pretreatment karyotype of leukemic blasts is currently the key determinant in therapy decision-making in acute myeloid leukemia (AML). However, approximately fifty percent of AML patients, often carrying a normal karyotype, are currently unclassifiable based these established methods. Gene expression profiling has proven to be valuable for risk stratification of AML. The gene expression profiles of AML samples of two independent cohorts (n=247 and n=214) were determined using Affymetrix U13...
Provenance — who produced it, who reused it
Linked to 41 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Base-Pair Resolution DNA Methylation Sequencing Reveals Profound... 2012 · 301 cites
- Notch pathway activation targets AML-initiating cell homeostasis... 2013 · 153 cites
- Notch activation inhibits AML growth and survival: a potential t... 2013 · 150 cites
- Epigenetic Identity in AML Depends on Disruption of Nonpromoter... 2017 · 145 cites
- EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rea... 2012 · 85 cites
- Therapeutic antagonists of microRNAs deplete leukemia-initiating... 2013 · 76 cites
35 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.
- Comprehensive analysis of m<sup>6</sup>A methylome alteratio... L1 No data access