Whole genome analysis for liver metastasis gene signitures in colorectal cancer
Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular events involved in tumor progression and metastasis. We performed experiments using a cDNA microarray containing 17,104 genes with the following tissue samples: paired tissues of 25 normal colorectal mucosa, 27 primary colorectal tumors, 13 normal...
Provenance — who produced it, who reused it
Linked to 13 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The POU2F1-ALDOA axis promotes the proliferation and chemoresist... 2022 · 138 cites
- PCK1 and DHODH drive colorectal cancer liver metastatic coloniza... 2019 · 95 cites
- TRIP13 promotes tumor growth and is associated with poor prognos... 2018 · 89 cites
- PKLR promotes colorectal cancer liver colonization through induc... 2016 · 86 cites
- A novel genome‐wide in vivo screen for metastatic suppressors in... 2014 · 83 cites
8 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently