Genome wide DNA methylation profiling of normal breast, normal adjacent and breast cancer tissue
The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 480,000 CpGs in a total of 407 samples, including 50 normal samples from healthy women, 42 matched normal-adjacent breast cancer pairs (84 samples), 263 unmatched breast cancers, 7 normal samples from BRCA1 carriers and 4 BRCA1 breast cancers. ***WARNING: incomplete metadata supplied for this study***
Provenance — who produced it, who reused it
Linked to 20 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Identification of differentially methylated cell types in epigen... 2018 · 360 cites
- A comparison of epigenetic mitotic-like clocks for cancer risk p... 2020 · 153 cites
- Integrative analysis identifies potential DNA methylation biomar... 2019 · 128 cites
- EPISCORE: cell type deconvolution of bulk tissue DNA methylomes... 2020 · 119 cites
- Large-scale analysis of DFNA5 methylation reveals its potential... 2018 · 106 cites
13 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently