Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
Histone modifications are considered as fundamental epigenetic regulators that control many crucial cellular processes 1. However, whether these marks can be passed on from gametes to the next generation in mammals is a long-standing question that remains unclear. By developing a highly sensitive approach, STAR ChIP-seq, we provided a panoramic view of the landscape of H3K4me3, a histone hallmark for transcription initiation 2, from developing gametes to postimplantation embryos. Interestingly,...
Provenance — who produced it, who reused it
Linked to 25 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrative single-cell analysis of transcriptome, DNA methylome... 2018 · 181 cites
- Single-cell multiomics sequencing reveals the functional regulat... 2021 · 160 cites
- Genome–lamina interactions are established de novo in the early... 2019 · 158 cites
- Characterization of zygotic genome activation-dependent maternal... 2019 · 149 cites
- Epigenomic analysis of gastrulation identifies a unique chromati... 2019 · 138 cites
- Allelic H3K27me3 to allelic DNA methylation switch maintains non... 2019 · 120 cites
- Sperm histone H3 lysine 4 trimethylation is altered in a genetic... 2020 · 110 cites
- Sperm histone H3 lysine 4 tri-methylation serves as a metabolic... 2022 · 102 cites
- New insights on human essential genes based on integrated analys... 2019 · 100 cites
16 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published ChIP-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0