Insights into function and regulation of microRNAs by decoding degradation dynamics [4SU]
The regulation of the miRNA pool is one of the critical events in the definition of cell identity and behavior both in steady-state condition as well during cell transitions. While mechanisms controlling biogenesis have received much attention, little is known about how miRNA are turned over, due to the lack of proper approaches to analyze miRNA decay without globally perturbing gene transcription or miRNA biogenesis. To overcome such limitations we developed a “pulse-chase” approach for the ana...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Degradation dynamics of microRNAs revealed by a novel pulse-chas... 2016 · 191 cites
- Endogenous transcripts control miRNA levels and activity in mamm... 2018 · 170 cites
Deep data QC
83/100 · BStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The B grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0