CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription
Spatial genome organization and its effect on transcription remains a fundamental biological question. We applied an advanced ChIA-PET strategy to comprehensively map higher-order chromosome folding and chromatin interactions mediated by CTCF and RNAPII with haplotype specificity and nucleotide resolution in different human cell lineages. We find that CTCF-mediated interaction anchors serve as structural foci for spatial organization of constitutive genes concordant with CTCF-motif orientation,...
Provenance — who produced it, who reused it
Linked to 17 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell... 2018 · 910 cites
- Epigenomic profiling of primary gastric adenocarcinoma reveals s... 2016 · 160 cites
- A curated benchmark of enhancer-gene interactions for evaluating... 2020 · 124 cites
- Co-opted transposons help perpetuate conserved higher-order chro... 2020 · 100 cites
- An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific E... 2018 · 98 cites
- Multiomic Profiling Identifies cis-Regulatory Networks Underlyin... 2019 · 82 cites
9 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently