Distinct features in establishing H3K4me3 and H3K27me3 in pre-implantation embryos
Histone modifications play critical roles in regulating developmental genes expression during embryo development in mammals1,2. However, genome-wide analysis of histone modifications in pre-implantation embryos has been impeded by technical difficulties and the scarcity of required materials. Here, by using a small-scale chromatin immunoprecipitation sequencing (ChIP-seq) method3, for the first time, we mapped the genome-wide profile of histone H3 lysine 4 trimethylation (H3K4me3) and histone H3...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Single-cell multiomics sequencing reveals the functional regulat... 2021 · 160 cites
- Allelic H3K27me3 to allelic DNA methylation switch maintains non... 2019 · 120 cites
- Sperm histone H3 lysine 4 trimethylation is altered in a genetic... 2020 · 110 cites
- Sperm histone H3 lysine 4 tri-methylation serves as a metabolic... 2022 · 102 cites
12 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently