Histone H3 lysine 4 monomethylation modulates longrange chromatin interactions at enhancers
Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that the enhancer-specific histone H3 lysine 4 monomethylation (H3K4me1) and the histone methyltransferases MLL3 and MLL4 (MLL3/4) play an active role in this process. We demonstrate that...
Provenance — who produced it, who reused it
Linked to 4 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Histone H3 lysine 4 monomethylation modulates long-range chromat... 2018 · 198 cites
- H3K4me1 facilitates promoter-enhancer interactions and gene acti... 2024 · 85 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
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