A developmental coordinate of the spectrum of pluripotency among mice, monkeys, and humans
The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of the spectrum of pluripotent stem cells (PSCs) in vitro. To explore the ontogeny of human/primate pluripotency, we performed comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys. Here we show that after specification in the blastocysts [embryonic day (E)7], cyEPI undergoes major transcriptome changes upon implantation. Thereafter, cyEPI, while generating gastr...
Provenance — who produced it, who reused it
Linked to 14 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Human naive epiblast cells possess unrestricted lineage potentia... 2021 · 346 cites
- Capture of Mouse and Human Stem Cells with Features of Formative... 2020 · 272 cites
- Pluripotent stem cell-derived model of the post-implantation hum... 2023 · 224 cites
- Human Primordial Germ Cells Are Specified from Lineage-Primed Pr... 2019 · 202 cites
- Comprehensive Cell Surface Protein Profiling Identifies Specific... 2017 · 189 cites
- Spatial profiling of early primate gastrulation in utero 2022 · 159 cites
- An Intermediate Pluripotent State Controlled by MicroRNAs Is Req... 2018 · 84 cites
- Cross-species single-cell transcriptomic analysis reveals pre-ga... 2021 · 79 cites
- GATA transcription factors, SOX17 and TFAP2C, drive the human ge... 2021 · 73 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
45/100 · FStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The F grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0