ATAC-seq data
A single hematopoietic stem cell can give rise to all blood cells with remarkable fidelity. Here, we define the chromatin accessibility and transcriptional landscape controlling this process in thirteen primary cell types that traverse the hematopoietic hierarchy. Exploiting the finding that enhancer landscapes better reflect cell identity than mRNA levels, we enable "enhancer cytometry" for accurate enumeration of pure cell types from complex populations. We further reveal the lineage ontogeny...
Provenance — who produced it, who reused it
Linked to 49 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Comprehensive Integration of Single-Cell Data 2019 · 16,818 cites
- ArchR is a scalable software package for integrative single-cell... 2021 · 1,452 cites
- Lineage-Specific Genome Architecture Links Enhancers and Non-cod... 2016 · 1,170 cites
- cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq... 2019 · 535 cites
- Identification of transcription factor binding sites using ATAC-... 2019 · 510 cites
- Landscape of stimulation-responsive chromatin across diverse hum... 2019 · 319 cites
- Inference of transcription factor binding from cell-free DNA ena... 2019 · 275 cites
- Identification of LZTFL1 as a candidate effector gene at a COVID... 2021 · 186 cites
- Molecular transitions in early progenitors during human cord blo... 2018 · 173 cites
- Single-cell lineage tracing by endogenous mutations enriched in... 2019 · 148 cites
- Chromatin-accessibility estimation from single-cell ATAC-seq dat... 2021 · 132 cites
- Impact of constitutional TET2 haploinsufficiency on molecular an... 2019 · 93 cites
36 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently