Single cell RNA sequencing of primary breast cancer.
We performed single cell RNA sequencing (RNA-seq) for 549 primary breast cancer cells and lymph node metastases from 11 patients with distinct molecular subtypes (BC01-BC02, estrogen receptor positive (ER+); BC03, double positive (ER+ and HER2+); BC03LN, lymph node metastasis of BC03; BC04-BC06, human epidermal growth factor receptor 2 positive (HER2+); BC07-BC11, triple-negative breast cancer (TNBC); BC07LN, lymph node metastasis of BC07) and matched bulk tumors. We separated these single cells...
Provenance — who produced it, who reused it
Linked to 58 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Machine Learning Identifies Stemness Features Associated with On... 2018 · 2,344 cites
- Classification of triple-negative breast cancers based on Immuno... 2018 · 698 cites
- scGNN is a novel graph neural network framework for single-cell... 2021 · 457 cites
- CD63<sup>+</sup> Cancer‐Associated Fibroblasts Confer Tamoxifen... 2020 · 146 cites
- A gene regulatory network to control EMT programs in development... 2019 · 131 cites
- Integration of single-cell RNA-seq data into population models t... 2019 · 122 cites
- Bulk and single-cell transcriptome profiling reveal the metaboli... 2021 · 111 cites
- Genomic and microenvironmental heterogeneity shaping epithelial-... 2023 · 92 cites
- Using single nucleotide variations in single-cell RNA-seq to ide... 2018 · 88 cites
- Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor... 2018 · 74 cites
47 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.