Resetting epigenetic memory by reprogramming of histone modifications in mammals
Polycomb group proteins and the related histone modification H3K27me3 can maintain the silencing of key developmental regulators and provide cellular memory. However, how such epigenetic state is reprogrammed and inherited between generations is poorly understood. Using an ultra-sensitive approach STAR ChIP-seq, we investigated H3K27me3 across 14 developmental stages along mouse gametogenesis and early development. Interestingly, highly pervasive H3K27me3 was found in regions depleted of transcr...
Provenance — who produced it, who reused it
Linked to 11 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Maternal H3K27me3 controls DNA methylation-independent imprintin... 2017 · 488 cites
- Integrative single-cell analysis of transcriptome, DNA methylome... 2018 · 181 cites
- Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Emb... 2018 · 138 cites
- Allelic H3K27me3 to allelic DNA methylation switch maintains non... 2019 · 120 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published ChIP-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0