Genome-wide chromosomal conformation elucidates regulatory relationships in human brain development and disease
The demonstration that chromatin exhibits a complex 3 dimensional organization, whereby short and long distance physical interactions correspond to complex gene regulatory processes has opened a new window on understanding the functional organization of the human genome. Recently, chromatin remodeling has also been causally implicated in several neurodevelopmental disorders, including autism and schizophrenia. However, it remains unclear whether knowledge of chromosome organization in a tissue s...
Provenance — who produced it, who reused it
Linked to 14 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms ac... 2019 · 1,491 cites
- The Dynamic Landscape of Open Chromatin during Human Cortical Ne... 2018 · 366 cites
- Genetic Control of Expression and Splicing in Developing Human B... 2019 · 307 cites
- Disease-Associated Short Tandem Repeats Co-localize with Chromat... 2018 · 293 cites
- Epigenome-wide study uncovers large-scale changes in histone ace... 2018 · 269 cites
- A genome-wide association study of shared risk across psychiatri... 2019 · 225 cites
- The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatial... 2018 · 87 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently