Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
We reported RNA-seq transcriptome profiling of WT and Cripto KO ESC→EpiSC transition using the Illumina HiSeq platform. Whole-genome expression revealed that epiblast associated-genes were all severely reduced in absence of Cripto compare to WT. Interestingly, besides a set of common genes deregulated in both WT and Cripto KO ESC→EpiSC transition, we identified two different sets of genes that were uniquely deregulated. We find a large cluster of genes coding for components of the five respirato...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Multi-omic Profiling Reveals Dynamics of the Phased Progression... 2019 · 162 cites
1 further paper cites this accession but reuse could not be confirmed.
Deep data QC
100/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0