Allelic reprogramming of 3D chromatin architecture during early mammalian development
In mammals, chromatin organization undergoes drastic reprogramming after fertilization. However, the three-dimensional structure of chromatin and its reprogramming in preimplantation development remain poorly understood. Here, by developing a low-input Hi-C (genomewide chromosome conformation capture) approach, we examined the reprogramming of chromatin organization during early development in mice. We found that oocytes in metaphase II show homogeneous chromatin folding that lacks detectable to...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- A mechanism of cohesin‐dependent loop extrusion organizes zygoti... 2017 · 408 cites
- Disease-Associated Short Tandem Repeats Co-localize with Chromat... 2018 · 293 cites
- In situ genome sequencing resolves DNA sequence and structure in... 2021 · 210 cites
- Genome–lamina interactions are established de novo in the early... 2019 · 158 cites
- Attenuated chromatin compartmentalization in meiosis and its mat... 2019 · 141 cites
- DeepHiC: A generative adversarial network for enhancing Hi-C dat... 2020 · 104 cites
10 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently