Epigenetic Landscapes in Breast Cancer Cells
Chromatin architecture is essential to transcriptional regulation. Cancer cells undergo critical chromatin remodeling processes that interact with the activation or silencing of oncogenes or tumor suppressor genes. These processes, together with other alterations of the functional status of chromatins, are characterized by epigenetic marks such as covalent histone modifications, DNA methylations and etc. The epigenetic landscapes defined by these marks are key to understand their regulatory mech...
Provenance — who produced it, who reused it
Linked to 20 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- UALCAN: An update to the integrated cancer data analysis platfor... 2022 · 2,521 cites
- Opposing Functions of BRD4 Isoforms in Breast Cancer 2020 · 207 cites
- Defining super-enhancer landscape in triple-negative breast canc... 2021 · 150 cites
- SMARCAL1 is a dual regulator of innate immune signaling and PD-L... 2024 · 93 cites
- Histone modification profiling in breast cancer cell lines highl... 2018 · 89 cites
14 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.