Transcriptome profile of human colorectal adenomas.
Background: Colorectal cancers are believed to arise predominantly from adenomas. Although these precancerous lesions have been subjected to extensive clinical, pathological, and molecular analyses, little is currently known about the global gene expression changes accompanying their formation. Results: To characterize the molecular processes underlying the transformation of normal colonic epithelium, we compared the transcriptomes of 32 prospectively collected adenomas with those of normal muco...
Provenance — who produced it, who reused it
Linked to 105 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor... 2019 · 338 cites
- The long noncoding RNA SNHG1 regulates colorectal cancer cell gr... 2018 · 322 cites
- lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and... 2019 · 244 cites
- Separate enrichment analysis of pathways for up- and downregulat... 2013 · 216 cites
- PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation 2013 · 186 cites
- Regulation of Tumor Initiation by the Mitochondrial Pyruvate Car... 2019 · 175 cites
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- Large Scale Gene Expression Meta-Analysis Reveals Tissue-Specifi... 2016 · 156 cites
- IgG Glycome in Colorectal Cancer 2016 · 135 cites
- Notch1 counteracts WNT/β-catenin signaling through chromatin mod... 2012 · 133 cites
- <scp>FAM</scp>83 family oncogenes are broadly involved in human... 2017 · 128 cites
- Exogenous and Endogenous Sources of Serine Contribute to Colon C... 2021 · 113 cites
- MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and f... 2020 · 105 cites
- Differential regulation of the REGγ–proteasome pathway by p53/TG... 2013 · 104 cites
- Comprehensive investigation of a novel differentially expressed... 2017 · 100 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- Long noncoding RNA LINC02418 regulates MELK expression by acting... 2019 · 90 cites
- TRIP13 promotes tumor growth and is associated with poor prognos... 2018 · 89 cites
- A distinct p53 target gene set predicts for response to the sele... 2015 · 87 cites
- Weighted Frequent Gene Co-expression Network Mining to Identify... 2012 · 86 cites
- Modulation of Age- and Cancer-Associated DNA Methylation Change... 2014 · 84 cites
- Targeting nonsense-mediated mRNA decay in colorectal cancers wit... 2018 · 83 cites
- Aberrant DNA methylation of WNT pathway genes in the development... 2016 · 81 cites
- <p>Potential Prognostic and Diagnostic Values of CDC6, CDC... 2019 · 74 cites
- Epithelial tumor suppressor ELF3 is a lineage-specific amplified... 2019 · 71 cites
55 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.