SCML2 establishes germline-specific bivalent domains.
Bivalent domains marked with repressive H3K27me3 and activating H3K4me2/3 are a molecular signature of totipotency in stem cells and development. While bivalent domains are retained throughout the germline to recover totipotency in the next generation, the mechanisms establishing bivalent domains remains unknown. Here we demonstrate that a germline-specific Polycomb protein, SCML2, binds to chromatin containing hypomethylated DNA to induce H3K27me3, thereby initiating the establishment of germli...
Provenance — who produced it, who reused it
Linked to 5 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Attenuated chromatin compartmentalization in meiosis and its mat... 2019 · 141 cites
- Polycomb protein SCML2 facilitates H3K27me3 to establish bivalen... 2018 · 92 cites
- Super-enhancer switching drives a burst in gene expression at th... 2020 · 77 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
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measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently