Molecular portraits of tumor mutational and micro-environmental sculpting by immune checkpoint blockade therapy
Immune checkpoint blockade (ICB) has demonstrated significant promise for the treatment of advanced malignancies. Anti-CTLA4 and ant-PD1 therapy can activate the immune system and result in durable control in diseases such as melanoma and non-small cell lung cancer.
Provenance — who produced it, who reused it
Linked to 117 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Defining T Cell States Associated with Response to Checkpoint Im... 2018 · 2,038 cites
- Molecular and pharmacological modulators of the tumor immune con... 2019 · 1,679 cites
- ImmuCellAI: A Unique Method for Comprehensive T‐Cell Subsets Abu... 2020 · 1,026 cites
- Exaggerated false positives by popular differential expression m... 2022 · 315 cites
- A gene expression signature of TREM2hi macrophages and γδ T cell... 2020 · 246 cites
- Ablation of the endoplasmic reticulum stress kinase PERK induces... 2022 · 155 cites
- Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark... 2020 · 154 cites
- T-cell exhaustion signatures characterize the immune landscape a... 2023 · 153 cites
- Cancer immunotherapies transition endothelial cells into HEVs th... 2022 · 152 cites
- FBXO44 promotes DNA replication-coupled repetitive element silen... 2020 · 110 cites
- Tumor-intrinsic YTHDF1 drives immune evasion and resistance to i... 2023 · 95 cites
- SMARCAL1 is a dual regulator of innate immune signaling and PD-L... 2024 · 93 cites
- PTEN loss correlates with T cell exclusion across human cancers 2021 · 91 cites
- Integrated multiomics analysis and machine learning refine molec... 2023 · 79 cites
- A pan-cancer transcriptome analysis of exitron splicing identifi... 2021 · 74 cites
- Pan-Cancer Analysis Reveals a Distinct Neutrophil Extracellular... 2022 · 71 cites
64 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.