Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen
Background: Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with regard to their clinical behavior and response to therapies. The ER is currently the best predictor of response to the anti-estrogen agent tamoxifen, yet up to 30-40% of ER+BC will relapse despite tamoxifen treatment. New prognostic biomarkers and further biological understanding of tamoxifen resistance are required. We used gene expression profiling to develop an outcome-based predictor using a training set...
Provenance — who produced it, who reused it
Linked to 80 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- LINC02273 drives breast cancer metastasis by epigenetically incr... 2019 · 222 cites
- Kinesin Family Deregulation Coordinated by Bromodomain Protein A... 2014 · 214 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Changes of N6-methyladenosine modulators promote breast cancer p... 2019 · 168 cites
- Identification of Prognosis-Relevant Subgroups in Patients with... 2013 · 161 cites
- Downregulation of long noncoding RNA MALAT1 induces epithelial-t... 2015 · 151 cites
- EMT is associated with an epigenetic signature of ECM remodeling... 2019 · 148 cites
- BreastMark: An Integrated Approach to Mining Publicly Available... 2013 · 143 cites
- Hypoxia-induced p53 modulates both apoptosis and radiosensitivit... 2015 · 141 cites
- DEAD-box helicase DP103 defines metastatic potential of human br... 2014 · 131 cites
- Portraying breast cancers with long noncoding RNAs 2016 · 116 cites
- The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various C... 2016 · 112 cites
- High-throughput RNAi screening for novel modulators of vimentin... 2012 · 107 cites
- Discovery of potential prognostic long non-coding RNA biomarkers... 2016 · 103 cites
- Oncometabolite lactate enhances breast cancer progression by orc... 2023 · 95 cites
- Mitohormesis Primes Tumor Invasion and Metastasis 2019 · 94 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- Reprogramming of Amino Acid Transporters to Support Aspartate an... 2019 · 83 cites
- PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 s... 2018 · 83 cites
- Reprogramming metabolism by histone methyltransferase NSD2 drive... 2016 · 83 cites
- A mechanistic model captures the emergence and implications of n... 2021 · 79 cites
- Downregulation of the FTO m6A RNA demethylase promotes EMT-media... 2021 · 78 cites
- Therapeutically targeting tumor microenvironment–mediated drug r... 2018 · 76 cites
- Cyclin D1 induction of Dicer governs microRNA processing and exp... 2013 · 74 cites
- SPHK1 regulates proliferation and survival responses in triple-n... 2014 · 73 cites
53 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently