Abnormal Expression Changes in AML
Acute myeloid leukemia (AML) is one of the most common and deadly forms of hematopoietic malignancies. We hypothesized that microarray studies could identify previously unrecognized expression changes that only occur only in AML blasts. We were particularly interested in those genes with increased expression in AML, believing that these genes may be potential therapeutic targets.
Provenance — who produced it, who reused it
Linked to 36 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- High Fructose Drives the Serine Synthesis Pathway in Acute Myelo... 2020 · 86 cites
- Ranking metrics in gene set enrichment analysis: do they matter? 2017 · 80 cites
- A Systems Approach to Predict Oncometabolites via Context-Specif... 2014 · 76 cites
31 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently