Multi-scale 3D genome rewiring during mouse neural development
Chromosome conformation capture technologies have revealed important insights into genome folding. Yet, how spatial genome architecture is related to gene expression and cell fate remains unclear. We mapped comprehensively 3D chromatin organization during mouse neural differentiation in vitro and in vivo, generating the highest resolution Hi-C maps available to date. We found that transcription is correlated with chromatin insulation and long-range interactions, but dCas9-mediated activation is...
Provenance — who produced it, who reused it
Linked to 52 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrated spatial genomics reveals global architecture of singl... 2021 · 439 cites
- Predicting 3D genome folding from DNA sequence with Akita 2020 · 325 cites
- Comparison of computational methods for the identification of to... 2018 · 262 cites
- DeepC: predicting 3D genome folding using megabase-scale transfe... 2020 · 230 cites
- A non-canonical BRD9-containing BAF chromatin remodeling complex... 2018 · 221 cites
- Regulation of single-cell genome organization into TADs and chro... 2020 · 220 cites
- High-resolution Repli-Seq defines the temporal choreography of i... 2020 · 179 cites
- Chromatin interaction analyses elucidate the roles of PRC2-bound... 2020 · 159 cites
- MeCP2 Represses the Rate of Transcriptional Initiation of Highly... 2019 · 122 cites
- Loop stacking organizes genome folding from TADs to chromosomes 2023 · 121 cites
- Enhancer accessibility and CTCF occupancy underlie asymmetric TA... 2019 · 113 cites
- CTCF modulates allele-specific sub-TAD organization and imprinte... 2019 · 96 cites
- Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining... 2020 · 95 cites
- Spatial Genome Re-organization between Fetal and Adult Hematopoi... 2019 · 89 cites
- In vivo dissection of a clustered-CTCF domain boundary reveals d... 2022 · 85 cites
- Differential methylation of enhancer at IGF2 is associated with... 2019 · 85 cites
- HiCNN: a very deep convolutional neural network to better enhanc... 2019 · 85 cites
- MeCP2 Represses Enhancers through Chromosome Topology-Associated... 2019 · 80 cites
- Quantitative prediction of enhancer–promoter interactions 2019 · 78 cites
32 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published ChIP-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0