GSE96654

Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity

We adapted ChIP-Rx method established in cells to fly tissues for quantitative ChIP-seq. We found the deposition of H3K27me3 during aging loses fidelity, resulting its propagation across the epigenome; lowering H3K27me3 by PRCs-deficiency promotes healthy lifespan by mitigating this trend. Quantitative multi-omic analysis converges on a central role of glycolysis, linking H3K27me3 dynamics to the regulation of glycolytic genes, which correspondingly rewire cellular metabolic homeostasis includi...

Provenance — who produced it, who reused it

Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.

Standardized, field-standard QC computed by touching the data — every metric states how it was obtained

No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.

measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently