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STAN, a computational framework for inferring spatially informed transcription factor activity.
PMID 41521668 · PMC12784991 · Nucleic acids research · 2026 · 7 claims · 7 setups
STAN, a linear mixed-effects (spatially weighted regression) model, integrates TF-target gene priors, gene expression, spatial coordinates, and histological image features to predict spot-specific TF activity in spatial transcriptomics data