Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype.

  PMID 18648492 · PMC2447155 · PloS one · 2008 · 8 claims · 5 setups

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  APP23 transgenic mice show significant protein spot alterations versus wildtype in cortex and hippocampus at all examined ages (ED16, 1, 2, 7, 15 months), largely preceding amyloid plaque formation

  hippocampus cortex significantly 2-d mass immunoblot

• An open-source representation for 2-DE-centric proteomics and support infrastructure for data storage and analysis.

  PMID 18179696 · PMC2231339 · BMC bioinformatics · 2008 · 8 claims · 4 setups

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  AGML 2.0 is a comprehensive XML representation for 2-DE experiments comprising identification, protocol (MI2DG), and gel sections

  general gel excised clinical 2-dimensional differential mass

• Proteomics of human neurodegenerative diseases.

  PMID 18800015 · PMC2710115 · Journal of neuropathology and experimental neurology · 2008 · 8 claims · 8 setups

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  Proteomic techniques applied to autopsy brain and CSF from patients with neurodegenerative diseases provide insight into pathogenesis and enable biomarker discovery

  detergent-extractable thioflavin-s-stained tau-2-immunostained snca-immunoreactive 2-dimensional laser lc-ms-ms

• A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries.

  PMID 18715566 · PMC2659534 · Atherosclerosis · 2009 · 6 claims · 4 setups

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  Stable and unstable carotid plaque extracts show distinct 2D-PAGE protein expression profiles, with nine proteins significantly differing in abundance between the two groups

  carotid excised 2-dimensional maldi-tof western

• Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection.

  PMID 17217429 · PMC2064037 · Cellular microbiology · 2007 · 6 claims · 3 setups

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  Proteomic analysis (2-DGE coupled with ADI-MS/MS) identified 250 unique exoproteins produced by MW2 and LAC culture supernatants during growth in vitro.

  mw2 mice neutrophils 2-dimensional infection confocal

• Mobile phone radiation might alter protein expression in human skin.

  PMID 18267023 · PMC2258283 · BMC genomics · 2008 · 7 claims · 1 setups

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  Local RF-EMF exposure of human skin may alter protein expression in living volunteers

  forearm 2-dimensional

• Placental proteomics: a shortcut to biological insight.

  PMID 19070895 · PMC3532024 · Placenta · 2009 · 7 claims · 5 setups

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  Developed a novel small cationic colloidal silica (smCCS) method to uniformly enrich the apical plasma membrane of the syncytiotrophoblast (STB) for proteomics analysis

  placenta smccs-coated electron 2-dimensional immunoblot

• Comparative proteomic analysis of malformed umbilical cords from somatic cell nuclear transfer-derived piglets: implications for early postnatal death.

  PMID 19889237 · PMC2783166 · BMC genomics · 2009 · 8 claims · 8 setups

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  scNT-MUC exhibit complete occlusive thrombi and absence of columnar epithelial layers not seen in control or scNT-N umbilical cords

  umbilical porcine puvec histology immunostaining real-time

• Biomarker discovery in neurodegenerative diseases: a proteomic approach.

  PMID 18938247 · PMC2939006 · Neurobiology of disease · 2009 · 6 claims · 8 setups

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  Proteomic profiling of CSF and plasma can identify candidate protein biomarkers that distinguish AD patients from controls with high sensitivity and specificity

  csf plasma brain 2-dge lc-ms seldi-tof-ms

• Applying proteomics to the diagnosis and treatment of ALS and related diseases.

  PMID 19670321 · PMC2836583 · Muscle & nerve · 2009 · 8 claims · 8 setups

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  Protein-based biomarkers for ALS/MND require further verification and large-scale validation/qualification studies, including disease mimics, before clinical use

  csf spinal biofluid muscle 2d-dige antibody luminex

• Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.

  PMID 18824761 · PMC2629397 · Circulation · 2008 · 8 claims · 3 setups

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  CP/CPB causes multiple consistent, reproducible changes in the human myocardial (right atrial) protein profile

  right excised 2-dimensional tandem sds-page

• Human neuronal cell protein responses to Nipah virus infection.

  PMID 17553172 · PMC1896155 · Virology journal · 2007 · 8 claims · 4 setups

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  NiV infection induces differential protein expression in SK-N-MC human neuronal cells detectable by 2D-PAGE

  sk-n-mc spots 2d-page maldi-tof tandem

• Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.

  PMID 18784066 · PMC2713027 · Molecular & cellular proteomics : MCP · 2009 · 7 claims · 5 setups

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  A mitochondria-enriched 2-D DIGE plus MALDI-TOF/TOF proteomics workflow can define a characteristic mitochondrial protein profile of OA chondrocytes.

  articular chondrocytes 2-d real western

• The use of neuroproteomics in drug abuse research.

  PMID 19926406 · PMC3947580 · Drug and alcohol dependence · 2010 · 8 claims · 8 setups

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  Neuroproteomic technologies (2D-DIGE, iTRAQ, ICAT, etc.) enable identification of protein-level changes underlying effects of drugs of abuse such as amphetamine, morphine, cocaine, and alcohol.

  rodent brain postmortem sectioned 2d-dige itraq heat

• Detection of venous thromboembolism by proteomic serum biomarkers.

  PMID 17579716 · PMC1891085 · PloS one · 2007 · 5 claims · 8 setups

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  A neural network-based classifier built from direct MALDI-TOF MS serum protein expression profiles can diagnose VTE with sensitivity/specificity that exceeds D-dimer assays

  serum anova-selected citrated depleted direct artificial d-dimer