Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 407

Assay: acid ✕ Clear

Evidence for limited genetic compartmentalization of HIV-1 between lung and blood.

PMID 19759830 · PMC2736399 · PloS one · 2009 · 8 claims · 7 setups

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Statistical evidence of genetic compartmentalization between lung and blood HIV-1 env sequences was found in 10 of 18 subjects.

paired lung tissue-pair pooled hiv-1 maximum statistical
Research Spotlight: New multiparameter bioanalytical technologies for applications in personalized medicine, drug discovery and fundamental biology.

PMID 21083072 · PMC3106349 · Bioanalysis · 2009 · 8 claims · 8 setups

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High-density arrays of silicon photonic microring resonators enable label-free, multiplexed detection of DNA, miRNA, and protein biomarkers from a single small-volume sample

silicon undiluted model label-free multiplexed cytokine
Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients.

PMID 19698114 · PMC2749045 · BMC infectious diseases · 2009 · 8 claims · 7 setups

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Three PRNP mutations—D178N, E200K, and M232R—were identified in heterozygosity in Korean probable CJD patients, marking their first report in this population.

csf 293t genomic pcr western recombinant sequencing
Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.

PMID 19682357 · PMC2782262 · BMC microbiology · 2009 · 8 claims · 5 setups

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The RCA assay correctly identified all ERG11 mutations in eight 'reference' azole-resistant C. albicans isolates with known mutations.

clinical pcr template padlock sequencing antifungal
Phosphoproteomic analysis of human embryonic stem cells.

PMID 19664994 · PMC2726933 · Cell stem cell · 2009 · 8 claims · 6 setups

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MDLC-MS/MS phosphoproteomics identified 2546 phosphorylation sites on 1602 phosphoproteins in undifferentiated hESCs and their differentiated derivatives

esc hescs hesc-derived undifferentiated mdlc-ms immunocytochemistry western
Sequence variation of PfEMP1-DBLalpha in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria.

PMID 19650937 · PMC3224928 · Malaria journal · 2009 · 8 claims · 5 setups

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Sequence group 1 (mainly from uncomplicated malaria) is significantly different in distribution from sequence group 3 (mainly from severe malaria)

falciparum falciparum-infected pcr-amplified non-identical static rosette rt-pcr
Comparative transcriptome analysis of two pomelo accessions with different parthenocarpic ability provides insight into the molecular mechanisms of parthenocarpy in pomelo (Citrus grandis).

PMID 39135650 · PMC11317442 · Frontiers in plant science · 2024 · 6 claims · 6 setups

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G pomelo exhibits significantly higher parthenocarpic ability (ovary growth, cell division, fruit setting) than S pomelo following emasculation

pomelo ripe degs morphological phytohormone fruit
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

PMID 40981426 · PMC12877753 · Cancer discovery · 2026 · 8 claims · 7 setups

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FOLFIRI-resistant PDX tumors show transcriptional upregulation of innate immunity and mitochondrial metabolism genes and reduced expression of DNA polymerase POLD1

mcrc pdx patients patient-derived drug whole-exome bulk
A cost-effective and scalable barcoded library construction method for deep mutational scanning studies.

PMID 41671286 · PMC12923136 · PLoS biology · 2026 · 8 claims · 4 setups

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A two-step cloning strategy (Gibson assembly followed by Golden Gate assembly) using degenerate oligo pools (oPools) with co-synthesized DNA barcodes enables construction of scalable DMS libraries for large genes.

yeast short-read transformation barcode
Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae.

PMID 41766466 · PMC13147539 · Genetics · 2026 · 8 claims · 5 setups

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The three echinocandin resistance hotspots of Fks1 form a single, solvent-exposed, water-filled binding cavity spanning hotspot 1, 2, and 3

fks1 cerevisiae fks explicit-solvent site-directed deep-mutational
BaGPipe: an automated, reproducible, and flexible pipeline for bacterial genome-wide association studies.

PMID 41896736 · PMC13147680 · BMC microbiology · 2026 · 7 claims · 8 setups

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BaGPipe is an automated, reproducible Nextflow pipeline that integrates pre-processing, Pyseer-based association analysis, and downstream visualisation into a unified bacterial GWAS workflow

streptococcus staphylococcus aureus pneumoniae bacterial read amr
Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity
Immuno-metabolic dysregulation in type 2 diabetes is associated with altered neutrophil functional plasticity, mitochondrial dysfunction, and compromised responses in sepsis.

PMID 41520116 · PMC12882159 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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Proportions of functionally restricted neutrophil subpopulations (phagocytosis-only vs NETosis-only) are significantly altered in T2D and fail to elicit an immune response upon sepsis induction

peripheral bone plasma neutrophils flow bulk global
Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer.

PMID 41578129 · PMC12932634 · NPJ breast cancer · 2026 · 8 claims · 7 setups

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Identified 30 isolated tumor cells (ITCs) in a clinically metastasis-negative tumor-draining lymph node, representing the initial metastatic seeding event, spanning ~200 μm

dissected same tumor xenium-derived bulk enzymatic whole-genome
Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.

PMID 41654976 · PMC13113109 · Zoological letters · 2026 · 8 claims · 8 setups

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The majority (95-97%) of chemoreceptor genes are expressed in nasal/oral chemosensory organs across mouse, Xenopus, Polypterus, and zebrafish

mus zebrafish xenopus polypterus bulk single-cell molecular
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma.

PMID 41706364 · PMC12916967 · Cellular oncology (Dordrecht, Netherlands) · 2026 · 7 claims · 8 setups

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Cholesterol metabolic activity is markedly elevated in HCC tumors and in immune checkpoint blockade (ICB) non-responders, with pronounced intratumoral heterogeneity across malignant cell subpopulations

hcc tcga-lihc malignant hepa1-6 scrna-seq bulk hdwgcna
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis.

PMID 41714361 · PMC13022353 · EMBO reports · 2026 · 8 claims · 8 setups

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PHF8 is required for neural stem cell (NSC) proliferation in vitro

developing nscs embryonic single-cell shrna growth
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

PMID 41778850 · PMC7619144 · Cancer discovery · 2026 · 7 claims · 8 setups

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AT2 cells and surfactant lipids (e.g., PC, PE, PI, PG) are enriched in the vicinity of breast cancer lung metastases in both patients and mice

postmortem lungs lung at2 immunohistochemistry maldi-msi longitudinal
Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis.

PMID 41781333 · PMC7619044 · Genome research · 2026 · 8 claims · 8 setups

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There are few endoderm-specific CRMs; many CRMs governing pancreas development also likely act within the nervous system

zebrafish embryonic atac-seq bulk facs
How bacterial communities expand functional repertoires.

PMID 17238278 · PMC1750926 · PLoS biology · 2006 · 8 claims · 7 setups

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The human microbiome contains roughly 100 times as many genes as does the human genome

bacteroides distal interleukin-10-deficient macrophages transcriptional metagenomic microbiota

Experiments

Evidence for limited genetic compartmentalization of HIV-1 between lung and blood.

Research Spotlight: New multiparameter bioanalytical technologies for applications in personalized medicine, drug discovery and fundamental biology.

Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients.

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.

Phosphoproteomic analysis of human embryonic stem cells.

Sequence variation of PfEMP1-DBLalpha in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria.

Comparative transcriptome analysis of two pomelo accessions with different parthenocarpic ability provides insight into the molecular mechanisms of parthenocarpy in pomelo (Citrus grandis).

The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

A cost-effective and scalable barcoded library construction method for deep mutational scanning studies.

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae.

BaGPipe: an automated, reproducible, and flexible pipeline for bacterial genome-wide association studies.

Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

Immuno-metabolic dysregulation in type 2 diabetes is associated with altered neutrophil functional plasticity, mitochondrial dysfunction, and compromised responses in sepsis.

Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer.

Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.

Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma.

Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis.

Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis.

How bacterial communities expand functional repertoires.