Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction
RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.
PMID 29734338 · PMC5937737 · PLoS genetics · 2018 · 8 claims · 8 setups
PAK1 is a novel direct effector of RIT1
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Full-text index only
Glycoprotein structural genomics: solving the glycosylation problem.
PMID 17355862 · PMC1885966 · Structure (London, England : 1993) · 2007 · 8 claims · 5 setups
Transiently expressing glycoproteins in HEK293T cells with kifunensine or swainsonine allows correct folding while retaining endo H sensitivity, solving the glycosylation problem for structural genomics
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Full-text index only
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.
PMID 17186946 · PMC1860054 · Molecular & cellular proteomics : MCP · 2007 · 8 claims · 8 setups
Three complementary membrane-enrichment proteomic methods (lectin affinity, biotin/NeutrAvidin affinity, free flow electrophoresis) combined with LC-MS/MS identify 136 transmembrane proteins in human platelets, including many novel ones.
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Has reproduction · 50
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.
PMID 36149401 · PMC9576273 · eLife · 2022 · 8 claims · 8 setups
A C-terminal patch of the LRRK2 Armadillo domain (residues ~350–550, 'site #1') binds non-phosphorylated Rab29, Rab8A, and Rab10 with low-micromolar affinity