Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy.

  PMID 39805182 · PMC11780959 · Translational oncology · 2025 · 6 claims · 8 setups

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  A C3 PCLAF+ tumor cell subtype identified by scRNA-seq shows high proliferation/differentiation potential and is linked to aggressive tumor behavior and poor prognosis in HR+BC

  hr+bc mda-mb-361 tcga scrna-seq cellchat pyscenic

• Characterizing Response to PARP Inhibitor Treatment Combinations in Advanced Prostate Cancer.

  PMID 42193276 · PMC13203762 · Biomedicines · 2026 · 8 claims · 8 setups

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  PARPi + ARPi combinations are effective in ARPi-sensitive (C4-2B) and ARPi-resistant (AbiR, MDVR) prostate cancer models, but provide the greatest benefit in ARPi-sensitive cells

  c4-2b cck-8 morphology western

• Pre-implantation embryo metabolism identified by PEMA reveals endogenous lactate insufficiency contributes to pre-implantation development arrest.

  PMID 42272466 · PMC13247451 · Fundamental research · 2026 · 6 claims · 7 setups

  Has reproduction

  PEMA, a computational tool that weights metabolic reactions using Ribo-seq data combined with RNA-seq-derived flux balance analysis, can characterize metabolic states of human and mouse pre-implantation embryos more precisely than existing methods like Compass.

  embryos pre-implantation ch3pn single-embryo immunofluorescence single-cell

• E3RC: A step-by-step computational protocol for exploring enhancer RNA expression and regulation using conventional RNA-seq data.

  PMID 40716058 · PMC12318280 · STAR protocols · 2025 · 6 claims · 3 setups

  Has reproduction · 62

  E3RC is a computational framework for identifying and quantifying eRNAs and characterizing their expression and transcriptional regulation using conventional RNA-seq data.

  preimplantation genome erna bulk computational motif

• Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses.

  PMID 38482016 · PMC10933018 · Frontiers in immunology · 2024 · 8 claims · 8 setups

  Has reproduction · 80

  C3 PLP2+ Tumor Epithelial Progenitor Cells are a noteworthy subpopulation exerting a pivotal influence on CC differentiation and progression

  cervical tcga siha scrna-seq bulk rt-qpcr

• Identification of a novel lncRNA prognostic signature and analysis of functional lncRNA AC115619.1 in hepatocellular carcinoma.

  PMID 37614318 · PMC10442647 · Frontiers in pharmacology · 2023 · 8 claims · 8 setups

  Has reproduction · 87

  A six-lncRNA prognostic signature (LINC02428, LINC02163, AC008549.1, AC115619.1, CASC9, LINC02362) predicts overall survival in HCC patients

  hcc tcga paired snu-449 lncrna sequencing univariate

• miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.

  PMID 41811946 · PMC12978216 · Science advances · 2026 · 8 claims · 8 setups

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  miR-203 is required for a timely totipotency-to-pluripotency transition during early mouse embryogenesis

  preimplantation 8-cell mice mir-203 qrt-pcr genotyping time-lapse

• Colorectal cancer genomics: evidence for multiple genotypes which influence survival.

  PMID 11720434 · PMC2363933 · British journal of cancer · 2001 · 6 claims · 3 setups

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  Genetic grade (total number of CGH-detected gains+losses) varies greatly among Dukes' C CRC tumours and shows a multimodal (non-normal) distribution

  dukes colorectal comparative kaplan-meier

• SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo.

  PMID 41697236 · PMC12908936 · eLife · 2026 · 8 claims · 5 setups

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  Maternal SETDB1 is required for mouse preimplantation development beyond the eight-cell stage

  2-cell single-embryo degs embryo single-embryo principal

• TBP regulates transposable element expression in early mouse embryos.

  PMID 41862641 · PMC13144441 · The EMBO journal · 2026 · 8 claims · 6 setups

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  The general transcription factor TBP binds and activates MaLR transposable elements in mouse embryos

  single embryos computational embryonic rna-seq atac-seq motif

• Constructing an APOBEC-related gene signature with predictive value in the overall survival and therapeutic sensitivity in lung adenocarcinoma.

  PMID 37954334 · PMC10637964 · Heliyon · 2023 · 8 claims · 8 setups

  Has reproduction · 88

  APOBEC family genes are differentially expressed across cancer types and tissues, with APOBEC3B being the most aberrantly upregulated gene in most cancers including LUAD

  tcga tcga-luad beas-2b rna-seq somatic gene

• Interpretable prediction models for widespread m6A RNA modification across cell lines and tissues.

  PMID 37995291 · PMC10697738 · Bioinformatics (Oxford, England) · 2023 · 8 claims · 8 setups

  Has reproduction · 79

  CLSM6A is a set of CNN-based deep learning models that predict single-nucleotide-resolution m6A RNA modification sites across eight cell lines and three tissues in H. sapiens

  hct116 a549 brain hek293t miclip m6a-clip-seq m6a-seq

• Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy.

  PMID 41494534 · PMC12866099 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  VPNS@P selectively accumulates in immune cells within atherosclerotic plaques (predominantly macrophages and monocytes, partly T and B cells) with minimal off-target uptake by non-immune vascular cells

  vpns@p cell-free raw264.7 bone-marrow-derived tem ros-scavenging cck-8

• The reprogramming and function of H4K20me1 during early embryo development.

  PMID 42020515 · PMC13261155 · EMBO reports · 2026 · 7 claims · 8 setups

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  Low-input CUT&RUN (as few as 100 cells) reliably maps H4K20me1 and correlates strongly with conventional ChIP-seq

  k562 oocytes embryos zebrafish cut&run chip-seq immunofluorescence

• Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis.

  PMID 41540382 · PMC12892679 · Clinical proteomics · 2026 · 8 claims · 8 setups

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  PWAS integrating RA GWAS with ARIC and INTERVAL plasma pQTL data identified 35 genetically regulated proteins (42 associations) significantly associated with RA risk.

  plasma shared gtex blood proteome-wide two-sample bayesian

• The landscape and regulatory potential of eccDNAs in mammalian preimplantation embryos.

  PMID 41917015 · PMC13201599 · Nature communications · 2026 · 8 claims · 8 setups

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  eccDNA is widespread in mouse preimplantation embryos across all six developmental stages examined

  ivf-derived 2-cell preimplantation fibroblasts mda-based reverse chip-seq