Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 16

System / cell line: cd11b+ ✕ Assay: analysis ✕ Clear

Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures.

PMID 36527260 · PMC10952672 · Glia · 2023 · 6 claims · 3 setups

Has reproduction · 26

The bulk microglial and monocyte transcriptomic program is highly contingent on the disease environment, challenging the notion of a universal microglial disease signature

acutely microglia c57bl meta-analysis integration spectral
Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

PMID 41872134 · PMC13039919 · Cell death discovery · 2026 · 8 claims · 8 setups

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Prostaglandin-mediated immunosuppressive microenvironment formation is a critical contributor to chemotherapy resistance following cisplatin treatment

high-grade hgsoc bone bmdms scrna-seq cell-cell tensor
CD14(lo)CD301b(+) macrophages gathering as a proangiogenic marker in adipose tissues.

PMID 39645040 · PMC11745947 · Journal of lipid research · 2025 · 8 claims · 8 setups

Has reproduction · 59

Cd14−/− mice exhibit a leaner body shape and are protected from HFD-induced obesity compared to WT mice

epididymal adipose cd14low macrophage bulk scrna-seq pseudotime
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PMID 41547846 · PMC12910057 · NPJ breast cancer · 2026 · 8 claims · 8 setups

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Deletion of host Il1α causes rejection/regression of transplanted breast tumors

h605 pymt tumor-infiltrating two-week orthotopic flow single-cell
Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.

PMID 41638211 · PMC13091097 · Cell systems · 2026 · 8 claims · 7 setups

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A complex, intact gut microbiome is necessary for the steady-state transcriptional landscape of all major brain-resident cell types, with myelinating oligodendrocytes and immune cells showing the largest microbiome-dependent transcriptional response.

hippocampus cd11b+ intestinal brain single-nucleus bulk multiplex
VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

PMID 41776161 · PMC13194722 · Nature communications · 2026 · 8 claims · 8 setups

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VISTA deficiency significantly impairs PDAC tumor growth and prolongs survival in murine orthotopic models

pan02 cd45+ tumor mice orthotopic pharmacological flow
Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids.

PMID 41857366 · PMC13021996 · Communications biology · 2026 · 8 claims · 7 setups

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Microglia are essential for driving HIV-induced transcriptional changes and neuroinflammation in neural organoids

hipsc-derived neural mno supernatant flow elisa immunocytochemistry
Reinvigorating COTL1(high) NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.

PMID 41912896 · PMC13179135 · Nature cell biology · 2026 · 8 claims · 8 setups

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A COTL1-high NK cell subset mediates immune checkpoint blockade responsiveness in tsMHC-I impaired tumours

hcc sorted orthotopic multiplex bulk single-cell
Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

PMID 37572656 · PMC10576612 · Immunity · 2023 · 8 claims · 8 setups

Has reproduction · 68

Arg1 is highly and specifically induced in lung CD4+ T cells during in vivo influenza infection

flow-sort-purified lung cd4+ congenically rna-seq flow expression
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

PMID 18955570 · PMC2585845 · The Journal of experimental medicine · 2008 · 7 claims · 8 setups

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Familial primary PAP is caused by compound heterozygous mutations in CSF2RA: a paternal G174R point mutation and a maternal 1.6-Mb deletion at Xp22.33 encompassing CSF2RA.

peripheral pbmc blood lung flow western gm-csf
Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

PMID 41680858 · PMC12910993 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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IL4I1 mRNA expression is significantly elevated in AML compared to normal controls

tcga-laml bone thp-1-derived thp-1 bulk kaplan-meier deg
Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

PMID 38358352 · PMC10903300 · Cancer research communications · 2024 · 8 claims · 7 setups

Has reproduction · 64

Two main neutrophil subtypes exist in primary tumors: an activated subtype sharing transcriptomic signatures with healthy neutrophils, and a tumor-specific subtype.

colorectal sorted integrated neutrophil scrna-seq bulk immunohistochemistry
Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus.

PMID 41501166 · PMC12936121 · Communications biology · 2026 · 8 claims · 6 setups

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A combination of CD10−CD49d+Igκ+ surface markers identifies an immature low-density neutrophil (LDN) subset that is distinct from CD10+ mature high-density neutrophils (HDNs)

peripheral facs-sorted decidua pregnant infinityflow conventional may-grünwald
DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response.

PMID 41707654 · PMC12923980 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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DeCAF is a single-sample kTSP classifier using 9 TSP gene pairs that predicts proCAF vs restCAF subtypes from bulk expression data

pdac cptac external elyada-sc bulk single-sample classifier
Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice.

PMID 41922840 · PMC13171603 · Nature microbiology · 2026 · 8 claims · 7 setups

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Inflammatory macrophages accumulate in joint-associated tissue during the chronic stage of CHIKV infection and show an activated, pro-inflammatory, MHC-II+ transcriptional programme

ankle ipsilateral computational pfa-fixed rt-qpcr single-cell gene
The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence.

PMID 42118810 · PMC13189416 · PLoS computational biology · 2026 · 8 claims · 7 setups

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Differentiation of PUER progenitors into macrophages and neutrophils proceeds through cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic order.

puer kit+ bulk scrna-seq cut&run

Experiments

Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures.

Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

CD14(lo)CD301b(+) macrophages gathering as a proangiogenic marker in adipose tissues.

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids.

Reinvigorating COTL1(high) NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.

Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus.

DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response.

Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice.

The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence.